Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions.
نویسندگان
چکیده
A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.
منابع مشابه
An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions.
Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 65 شماره
صفحات -
تاریخ انتشار 2012